Nasal polyps, aspirin sensitivity, and late onset asthma are crucial to identify severe asthma. clinicaltrials.gov id : nct01513837
نویسندگان
چکیده
Background Early recognition of severe asthma may improve its management, modify its natural history by better approaching therapy and helps identifying patients resistant to current asthma therapy. Rhinitis and chronic rhinosinusitis are linked to asthma by clinical, epidemiological and similar inflammatory mechanisms which interrelates upper and lower airways. Evidence for high rate of chronic rhinosinusitis has been related to severe asthma.
منابع مشابه
Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future
Aspirin-exacerbated respiratory disease (AERD) is a late onset condition characterized by the Samter triad (aspirin sensitivity [as well as sensitivity to any nonselective cyclooxygenase inhibitor], nasal polyps, asthma) and additional features, including eosinophilic chronic rhinosinusitis, hypereosinophilia, anosmia, frequent absence of atopy, and, intolerance to ingestion of red wine and oth...
متن کاملThe prevalence of nasal polyps and the corresponding urinary LTE4 levels in severe compared to mild and moderate asthma.
BACKGROUND Several comorbid conditions may contribute to worsening asthma symptoms, including nasal polyps (NPs). Cysteinyl leukotrienes (Cys-LTs) play a crucial role in asthma pathophysiology, and specific receptors for CysLTs are reported as upregulated in nasal polyp tissues. The aim of the present study was to assess the prevalence of nasal polyps in severe vs. mild and moderate asthma, and...
متن کاملGenetics of aspirin induced asthma.
Aspirin induced asthma (AIA) is more common in women than in men. The first symptoms of the disease are often a viral respiratory infection which is followed by a prolonged and perennial rhinitis. Nasal congestion, anosmia, and rhinorrhoea are accompanied by nasal polyps which are found on physical examination in about half the patients. Within a few years bronchial asthma develops, characteris...
متن کاملCharacterization of aspirin-sensitivity in patients with asthma and chronic rhinosinusitis without a history of symptoms upon acetyl-salicylic acid (ASA) ingestion: a case series
Background Sensitivity to Non-steroidal Anti-inflammatory Drugs (NSAIDs) is a possible cause of exacerbations in patients with asthma. NSAID sensitivity associated to chronic rhinosinusitis with nasal polyps features Aspirin-Exacerbated Respiratory Disease (AERD). Patients with AERD generally require long-term treatment with inhaled corticosteroids for moderate to severe persistent asthma. Resp...
متن کاملDiagnostic Value of Clinical Parameters in the Prediction of Aspirin-Exacerbated Respiratory Disease in Asthma
PURPOSE Aspirin-exacerbated respiratory disease (AERD) has attracted a great deal of attention because of its association with increased asthma severity. However, oral aspirin challenge (OAC) to diagnose AERD is a time-consuming procedure, and some patients experience serious complications. Thus, we evaluated diagnostic values of non-invasive clinical parameters to predict AERD in asthmatic pat...
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2015